Tardbp^tm1Koya
Targeted Allele Detail

Summary

• Symbol: Tardbp^tm1Koya
• Name: TAR DNA binding protein; targeted mutation 1, Koji Yamanaka
• MGI ID: MGI:6450017
• Synonyms: TDP-deltaC
• Gene: Tardbp Location: Chr4:148696839-148711476 bp, - strand Genetic Position: Chr4, 78.77 cM
• Alliance: Tardbp^tm1Koya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283597
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Epitope tag, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A part of exon 6, encoding amino acid 274-414, was replaced with a 3FLAG tag to delete the C-terminal portion of the encoded protein. (J:283597)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tardbp Mutation: 60 strains or lines available

References

• Original: J:283597 Nishino K, et al., Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway. Acta Neuropathol Commun. 2019 Jul 25;7(1):118
• All: 1 reference(s)