Maea^tm1.1Psfr
Targeted Allele Detail

Summary

• Symbol: Maea^tm1.1Psfr
• Name: macrophage erythroblast attacher; targeted mutation 1.1, Paul S Frenette
• MGI ID: MGI:6449981
• Synonyms: Maea^floxed
• Gene: Maea Location: Chr5:33492916-33530638 bp, + strand Genetic Position: Chr5, 17.55 cM, cytoband B1
• Alliance: Maea^tm1.1Psfr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273065
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The EuMMCR targeting vector PG00141_Z_1_G10 was used to generate mutant mice by homologous recombination. An frt-lacZ-loxP-neomycin selection gene-loxP-frt construct was inserted 5' to exon 5, and a single loxP site was inserted 3' to exon 5. Flp-mediated recombination resulted in the removal of the lacZ gene and neomycin selection cassette, leaving loxP sites flanking exon 5. (J:273065)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Maea Mutation: 40 strains or lines available

References

• Original: J:273065 Wei Q, et al., Maea expressed by macrophages, but not erythroblasts, maintains postnatal murine bone marrow erythroblastic islands. Blood. 2019 Mar 14;133(11):1222-1232
• All: 2 reference(s)