Gt(ROSA)26Sor^{em2(CAG-Mir155)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em2(CAG-Mir155)Smoc}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• MGI ID: MGI:6449838
• Synonyms: Stop-155^fl
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em2(CAG-Mir155)Smoc} page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The targeting construct introduced into the locus a CAG promoter, floxed neomycin resistance stop cassette, and Mir155 encoding sequence. (J:290924)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1084 strains or lines available

References

• Original: J:290924 Chao G, et al., MiR-155 controls follicular Treg cell-mediated humoral autoimmune intestinal injury by inhibiting CTLA-4 expression. Int Immunopharmacol. 2019 Jun;71:267-276
• All: 1 reference(s)