Ripk3^em1Hbz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ripk3^em1Hbz
• Name: receptor-interacting serine-threonine kinase 3; endonuclease-mediated mutation 1, Haibing Zhang
• MGI ID: MGI:6449643
• Synonyms: Ripk3^delta
• Gene: Ripk3 Location: Chr14:56022452-56026314 bp, - strand Genetic Position: Chr14, 28.19 cM, cytoband C1
• Alliance: Ripk3^em1Hbz page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 12-bp deletion (TCCAGTGGGACT) on exon 3 was generated by CRISPR/Cas9 genome editing technology. This deletion results in a four-amino-acid (20QWDF23) deletion in the kinase domain of the encoded protein. (J:254599)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk3 Mutation: 34 strains or lines available

References

• Original: J:254599 Zhao Q, et al., RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice. Cell Rep. 2017 Apr 25;19(4):798-808
• All: 2 reference(s)