Rr149^em2Wsa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr149^em2Wsa
• Name: regulatory region 149; endonuclease-mediated mutation 2, Warren S Alexander
• MGI ID: MGI:6449637
• Synonyms: Igh^em2Wsa, muA^delta
• Gene: Rr149 Location: Chr12:113391193-113391206 bp Genetic Position: Chr12, Syntenic
• Alliance: Rr149^em2Wsa page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: The Ets- and Fli1-binding 14 bp muA region of the cEmu enhancer (Rr148), located in an intron between the Igh Cmu constant region segments and Jh joining region segments, was deleted by CRISPR/Cas9 genome editing technology. (J:292184)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr149 Mutation: 0 strains or lines available

References

• Original: J:292184 Ng AP, et al., An Erg-driven transcriptional program controls B cell lymphopoiesis. Nat Commun. 2020 Jun 15;11(1):3013
• All: 1 reference(s)