Rr148^em1Wsa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr148^em1Wsa
• Name: regulatory region 148; endonuclease-mediated mutation 1, Warren S Alexander
• MGI ID: MGI:6449636
• Synonyms: cEmu^delta, Igh^em1Wsa
• Gene: Rr148 Location: Chr12:113391013-113391258 bp Genetic Position: Chr12, Syntenic
• Alliance: Rr148^em1Wsa page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: The 200 bp core region cEmu of enhancer iEmu, located in an intron between the Igh Cmu constant region segments and Jh joining region segments, was deleted by CRISPR/Cas9 genome editing technology. (J:292184)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr148 Mutation: 0 strains or lines available

References

• Original: J:292184 Ng AP, et al., An Erg-driven transcriptional program controls B cell lymphopoiesis. Nat Commun. 2020 Jun 15;11(1):3013
• All: 1 reference(s)