Cdkn2a^em1Hwl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cdkn2a^em1Hwl
• Name: cyclin dependent kinase inhibitor 2A; endonuclease-mediated mutation 1, Han-Woong Lee
• MGI ID: MGI:6449245
• Synonyms: FVB-p16^Ink4a KO
• Gene: Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
• Alliance: Cdkn2a^em1Hwl page

Mutation origin

• Strain of Origin: FVB/NTac

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s), Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 25 bp deletion downstream of the start codon was generated by TALEN mediated excision in the FVB/N strain. This allele will encode only 11 amino acids (AAs) downstream of the mutation site, due to a frameshift-induced premature termination codon. (J:281699)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkn2a Mutation: 59 strains or lines available

References

• Original: J:281699 Park BM, et al., Generation of knockout mouse models of cyclin-dependent kinase inhibitors by engineered nuclease-mediated genome editing. Lab Anim Res. 2018 Dec;34(4):264-269
• All: 1 reference(s)