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C5ar1tm1.1(C5AR1)Cmac
Targeted Allele Detail
Nomenclature
Symbol: C5ar1tm1.1(C5AR1)Cmac
Name: complement component 5a receptor 1; targeted mutation 1.1, Charles R Mackay
MGI ID: MGI:6449073
Synonyms: hC5aR1+
Gene: C5ar1  Location: Chr7:15980668-15993465 bp, - strand  Genetic Position: Chr7, 8.77 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:292028
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
C5ar1tm1.1(C5AR1)Cmac expresses 1 gene
 
Mutation detailsThe human C5AR1 gene coding sequence (exon 2) and a loxP-flanked PGK-neomycin gene replaced the mouse gene exon 2 coding sequence. The PGK-neomycin gene was removed via cre-mediated recombination. The human gene is under the control of the endogenous mouse promoter. (J:292028)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any C5ar1 Mutation:  20 strains or lines available
References
Original:  J:292028 Lee H, et al., Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies. Nat Biotechnol. 2006 Oct;24(10):1279-84
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory