Adra1a^em1Afu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adra1a^em1Afu
• Name: adrenergic receptor, alpha 1a; endonuclease-mediated mutation 1, Akiyoshi Fukamizu
• MGI ID: MGI:6448414
• Synonyms: Adra1a^KO
• Gene: Adra1a Location: Chr14:66872700-67008617 bp, + strand Genetic Position: Chr14, 34.6 cM, cytoband D1
• Alliance: Adra1a^em1Afu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The very 5' end of the coding region in exon 2 was targeted using CRISPR/Cas9 technology, resulting in an deletion-insertion frameshift mutation (12 bp deletion, 5 bp insertion). (J:291756)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adra1a Mutation: 30 strains or lines available

References

• Original: J:291756 Nagano K, et al., Cooperative action of APJ and alpha1A-adrenergic receptor in vascular smooth muscle cells induces vasoconstriction. J Biochem. 2019 Nov 1;166(5):383-392
• All: 1 reference(s)