Adamts2^em2Mhat
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adamts2^em2Mhat
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 2; endonuclease-mediated mutation 2, Mitsuharu Hattori
• MGI ID: MGI:6448391
• Synonyms: ADAMTS-2delta245
• Gene: Adamts2 Location: Chr11:50492912-50698400 bp, + strand Genetic Position: Chr11, 30.78 cM
• Alliance: Adamts2^em2Mhat page

Mutation origin

• Strain of Origin: C57BL/6NCrSlc

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 1 was targeted with an sgRNA (5'-CCGCCCGCGAGCGTCCGGCTCGT-3') using CRISPR/Cas9 technology, resulting in a 245 bp deletion of most of exon 1 and some upstream sequence. (J:291718)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts2 Mutation: 57 strains or lines available

References

• Original: J:291718 Yamakage Y, et al., A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum. Mol Cell Neurosci. 2019 Oct;100:103401
• All: 1 reference(s)