Gria3^tm1.1Kssk
Targeted Allele Detail

Summary

• Symbol: Gria3^tm1.1Kssk
• Name: glutamate receptor, ionotropic, AMPA3 (alpha 3); targeted mutation 1.1, Kenji Sakimura
• MGI ID: MGI:6446940
• Synonyms: GluA3 KO
• Gene: Gria3 Location: ChrX:40489731-40767478 bp, + strand Genetic Position: ChrX, 23.19 cM
• Alliance: Gria3^tm1.1Kssk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272765
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP sequence and an frt-flanked pgk-neomycin selection cassette was inserted into a site 107 bp upstream of exon 11. A second loxP site was introduced into a site 113 bp downstream of exon 11. Exon 11 was deleted via Cre-mediated recombination in the germline. (J:272765)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gria3 Mutation: 12 strains or lines available

References

• Original: J:272765 Garcia-Hernandez S, et al., Impaired auditory processing and altered structure of the endbulb of Held synapse in mice lacking the GluA3 subunit of AMPA receptors. Hear Res. 2017 Feb;344:284-294
• All: 4 reference(s)