Mecp2^tm1Bdlv
Targeted Allele Detail

Summary

• Symbol: Mecp2^tm1Bdlv
• Name: methyl CpG binding protein 2; targeted mutation 1, Antonio Bedalov
• MGI ID: MGI:6444751
• Synonyms: MeCP2-FL-HR, Mecp2^LucHyg
• Gene: Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
• Alliance: Mecp2^tm1Bdlv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222245
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A luciferase/hygromycin resistance fusion cassette was introduced in frame immediately before the termination codon. No MECP2 protein is detectable in Western blots of hemizygous male brain tissue. (J:222245)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mecp2 Mutation: 41 strains or lines available

References

• Original: J:222245 Wang J, et al., Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature. 2015 May 21;521(7552):E1-4
• All: 2 reference(s)