Ubash3a^em1Ygch
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ubash3a^em1Ygch
• Name: ubiquitin associated and SH3 domain containing, A; endonuclease-mediated mutation 1, Yi-Guang Chen
• MGI ID: MGI:6444747
• Gene: Ubash3a Location: Chr17:31426847-31465866 bp, + strand Genetic Position: Chr17, 15.84 cM
• Alliance: Ubash3a^em1Ygch page

Mutation origin

• Strain of Origin: NOD/ShiLtJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This zinc finger nuclease induced mutation targets exon 9 creating a 4 bp deletion and early termination. (J:294213)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ubash3a Mutation: 32 strains or lines available

References

• Original: J:294213 Chen YG, et al., UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice. Sci Rep. 2020 Jul 21;10(1):12019
• All: 1 reference(s)