Runx1^tm6.1Itan
Targeted Allele Detail

Summary

• Symbol: Runx1^tm6.1Itan
• Name: runt related transcription factor 1; targeted mutation 6.1, Ichiro Taniuchi
• MGI ID: MGI:6441734
• Synonyms: Runx1^{deltaP1:P2TAA}
• Gene: Runx1 Location: Chr16:92398354-92622962 bp, - strand Genetic Position: Chr16, 53.7 cM
• Alliance: Runx1^tm6.1Itan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245723
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Intragenic deletion, Single point mutation
• Mutation details: A floxed neomycin resistance cassette replaced exons 1a and 1b. Cre-mediated recombination removed the selection cassette. The translation start codon, AUG, in exon 2 was replaced UAA to created an aberrant splice acceptor site. Another round of cre-mediated recombination removed the neomycin resistance cassette inserted into intron 2. (J:245723)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx1 Mutation: 34 strains or lines available

References

• Original: J:245723 Nieke S, et al., Unique N-terminal sequences in two Runx1 isoforms are dispensable for Runx1 function. BMC Dev Biol. 2017 Oct 18;17(1):14
• All: 1 reference(s)