Fmr1^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Fmr1^tm1Sud
• Name: fragile X messenger ribonucleoprotein 1; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:6441026
• Synonyms: Fmr1 cKO
• Gene: Fmr1 Location: ChrX:67722147-67761569 bp, + strand Genetic Position: ChrX, 34.83 cM
• Alliance: Fmr1^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267659
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6 x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A cassette incorporating FRT1-loxP1-FRT2-neomycin-FRT1-loxP2 and a copy of Exon3 carrying a 3xStop and mVenus-loxP2-FRT2 was introduced to intron 2, and a loxP1 site was placed in intron 3. The neomycin-FRT1-loxP2-Exon3*(Stop)-IRES-mVenus-loxP2 is skipped and non-functional, without Stop or fluorescent properties. (J:267659)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fmr1 Mutation: 29 strains or lines available

References

• Original: J:267659 Zhong LR, et al., Retinoic Acid Receptor RARalpha-Dependent Synaptic Signaling Mediates Homeostatic Synaptic Plasticity at the Inhibitory Synapses of Mouse Visual Cortex. J Neurosci. 2018 Dec 5;38(49):10454-10466
• All: 4 reference(s)