Ptprf^tm1.1Sud
Targeted Allele Detail

Summary

• Symbol: Ptprf^tm1.1Sud
• Name: protein tyrosine phosphatase receptor type F; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:6441013
• Synonyms: PTPRF cKO
• Gene: Ptprf Location: Chr4:118065410-118148602 bp, - strand Genetic Position: Chr4, 54.47 cM, cytoband C6-D1
• Alliance: Ptprf^tm1.1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287233
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag)
• Mutation: Insertion
• Mutation details: A loxP-FRT-neo-FRT cassette was introduced to intron 3, a 2X hemagglutinin (HA) tag was placed in front of the first immunoglobulin (Ig) domain in exon 4, and a loxP site was placed in intron 4. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:287233)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptprf Mutation: 99 strains or lines available

References

• Original: J:287233 Sclip A, et al., LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses. Elife. 2020 Jan 27;9:e53406
• All: 2 reference(s)