Atp1a3^em3Lutzy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Atp1a3^em3Lutzy
• Name: ATPase, Na+/K+ transporting, alpha 3 polypeptide; endonuclease-mediated mutation 3, Cathy Lutz
• MGI ID: MGI:6438218
• Synonyms: Atp1a3^{D801N L802L}
• Gene: Atp1a3 Location: Chr7:24677592-24705383 bp, - strand Genetic Position: Chr7, 13.73 cM
• Alliance: Atp1a3^em3Lutzy page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Plasmids encoding a signal guide RNA are designed to introduce the D801N point mutation in exon 17. An additional silent nucleotide change was introduced as part of the CRISPR/Cas9 targeting strategy. This change of CTG to CTA (L802L) has no effect on protein sequence. Correctly targeted pups were identified by sequencing and PCR. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Atp1a3 Mutation: 68 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)