Shank3^tm3.1Cmpl
Targeted Allele Detail

Summary

• Symbol: Shank3^tm3.1Cmpl
• Name: SH3 and multiple ankyrin repeat domains 3; targeted mutation 3.1, Craig M Powell
• MGI ID: MGI:6438111
• Gene: Shank3 Location: Chr15:89383826-89444464 bp, + strand Genetic Position: Chr15, 44.96 cM
• Alliance: Shank3^tm3.1Cmpl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:289884
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 4 to 9 were flanked by loxP sites and an FRT-flanked neomycin selection cassette was inserted downstream of the second loxP site. Flp-mediated recombination removed the selection cassette leaving exons 4-9 floxed. (J:289884)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shank3 Mutation: 87 strains or lines available

References

• Original: J:289884 Jaramillo TC, et al., Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4-9 Deletion Mouse Model of Autism. Autism Res. 2016 Mar;9(3):350-75
• All: 1 reference(s)