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Apptm1.1Dnli
Targeted Allele Detail
Nomenclature
Symbol: Apptm1.1Dnli
Name: amyloid beta (A4) precursor protein; targeted mutation 1, Pascal Sanchez
MGI ID: MGI:6437481
Synonyms: AppSAA
Gene: App  Location: Chr16:84751236-84972187 bp, - strand  Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:299724
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutation:    Nucleotide substitutions
 
Mutation detailsThe targeting vector was used to introduce the human R684H, F681Y, G676R and KM670/671NL (Swedish) mutations into to exon 16. An FRT-flanked PGK-neomycin cassette (in reverse transcriptional orientation), and an F3-flanked PGK-hygromycin cassette (in reverse transcriptional orientation) is placed in intron 16, and the E693G (Artic) and T714I (Austrian) mutations are introduced to exon 17. Flpe-mediated recombination removed the FRT-flanked neomycin and hygromycin cassettes. (J:299724)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any App Mutation:  65 strains or lines available
References
Original:  J:299724 Xia D, et al., Fibrillar Abeta causes profound microglial metabolic perturbations in a novel APP knock-in mouse model. bioRxiv. 2021;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory