Apptm1.1Dnli
Targeted Allele Detail
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Symbol: |
Apptm1.1Dnli |
Name: |
amyloid beta precursor protein; targeted mutation 1, Pascal Sanchez |
MGI ID: |
MGI:6437481 |
Synonyms: |
AppSAA |
Gene: |
App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
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Alliance: |
Apptm1.1Dnli page
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Germline Transmission: |
Earliest citation of germline transmission:
J:299724
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Humanized sequence) |
Mutation: |
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Nucleotide substitutions
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Mutation details: The targeting vector was used to introduce the human R684H, F681Y, G676R and KM670/671NL (Swedish) mutations into to exon 16. An FRT-flanked PGK-neomycin cassette (in reverse transcriptional orientation), and an F3-flanked PGK-hygromycin cassette (in reverse transcriptional orientation) is placed in intron 16, and the E693G (Artic) and T714I (Austrian) mutations are introduced to exon 17. Flpe-mediated recombination removed the FRT-flanked neomycin and hygromycin cassettes.
(J:299724)
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Original: |
J:299724 Xia D, et al., Fibrillar Abeta causes profound microglial metabolic perturbations in a novel APP knock-in mouse model. bioRxiv. 2021; |
All: |
3 reference(s) |
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