Vangl2^tm1.2Djhe
Targeted Allele Detail

Summary

• Symbol: Vangl2^tm1.2Djhe
• Name: VANGL planar cell polarity 2; targeted mutation 1.2, Deborah J Henderson
• MGI ID: MGI:6437454
• Gene: Vangl2 Location: Chr1:171828527-171856011 bp, - strand Genetic Position: Chr1, 79.54 cM
• Alliance: Vangl2^tm1.2Djhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228847
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was flanked by loxP sites and an FRT-flanked Neo-PGK cassette was inserted downstream of the floxed exon 4. Flp-mediated recombination removed the selection cassette and cre-mediated recombination deleted exon 4. (J:228847)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vangl2 Mutation: 30 strains or lines available

References

• Original: J:228847 Ramsbottom SA, et al., Vangl2-regulated polarisation of second heart field-derived cells is required for outflow tract lengthening during cardiac development. PLoS Genet. 2014 Dec;10(12):e1004871
• All: 3 reference(s)