Rock2^tm2.1Mrl
Targeted Allele Detail

Summary

• Symbol: Rock2^tm2.1Mrl
• Name: Rho-associated coiled-coil containing protein kinase 2; targeted mutation 2.1, Merck Research Laboratory
• MGI ID: MGI:6434881
• Synonyms: ROCK2^KD, Rock2^{tm1.1(K121A)Mrl}
• Gene: Rock2 Location: Chr12:16944896-17037824 bp, + strand Genetic Position: Chr12, 8.04 cM, cytoband A3
• Alliance: Rock2^tm2.1Mrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147112
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: The K121A point mutation was introduced into Rock2 exon 4. The positive selection marker (Puromycin resistance - PuroR) was flanked by FRT sites and inserted into intron 3. The constitutive point mutation allele was generated after Flp-mediated recombination. (J:147112)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rock2 Mutation: 62 strains or lines available

References

• Original: J:147112 Taconic, Information obtained from Taconic website. MGI Direct Data Submission. 2006-2017
• All: 2 reference(s)