Syk^tm2.1Mrl
Targeted Allele Detail

Summary

• Symbol: Syk^tm2.1Mrl
• Name: spleen tyrosine kinase; targeted mutation 2.1, Merck Research Laboratory
• MGI ID: MGI:6434795
• Gene: Syk Location: Chr13:52737209-52802828 bp, + strand Genetic Position: Chr13, 27.41 cM, cytoband B-C2
• Alliance: Syk^tm2.1Mrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147112
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: The K396R point mutation has been introduced into exon 10. The positive selection marker (Puromycin resistance - PuroR) was flanked by FRT sites and inserted into intron 9. The constitutive point mutation allele was generated after Flp-mediated recombination (J:147112)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syk Mutation: 45 strains or lines available

References

• Original: J:147112 Taconic, Information obtained from Taconic website. MGI Direct Data Submission. 2006-2017
• All: 1 reference(s)