Mapkap1^em1Bisu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mapkap1^em1Bisu
• Name: mitogen-activated protein kinase associated protein 1; endonuclease-mediated mutation 1, Bing Su
• MGI ID: MGI:6431788
• Synonyms: Sin1-R81T
• Gene: Mapkap1 Location: Chr2:34296783-34514962 bp, + strand Genetic Position: Chr2, 22.84 cM
• Alliance: Mapkap1^em1Bisu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: CRISPE/Cas9 genome editing technology was used to alter the nucleotides corresponding to codon 81 from ACG to TGC. This alters the residue in the encoded protein from arginine to threonine (R81T). (J:285126)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapkap1 Mutation: 45 strains or lines available

References

• Original: J:285126 Xu Y, et al., Sin1 (Stress-Activated Protein Kinase-Interacting Protein) Regulates Ischemia-Induced Microthrombosis Through Integrin alphaIIbbeta3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets. Arterioscler Thromb Vasc Biol. 2018 Dec;38(12):2793-2805
• All: 1 reference(s)