Ace2^{em2(cre/ERT2)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ace2^{em2(cre/ERT2)Smoc}
• Name: angiotensin converting enzyme 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• MGI ID: MGI:6430724
• Synonyms: Ace2^{em2(2A-CreERT2-WPRE-polyA)Smoc}
• Gene: Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Ace2^{em2(cre/ERT2)Smoc} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Ace2^{em2(cre/ERT2)Smoc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ace2 (MGI:1917258)

• Mutation details: CRISPR/Cas9 genome editing technology was used to insert a viral 2A oligopeptide that mediates ribosomal skipping and a Cre/ERT2-Wpre-polyA expression cassette into the gene stop codon. (J:238766)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ace2 (mouse) Summary of all recombinase alleles driven by Ace2. Alliance mouse Ace2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ace2 Mutation: 54 strains or lines available

References

• Original: J:238766 Shanghai Model Organisms Center, Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China. MGI Direct Data Submission. 2017
• All: 1 reference(s)