Il1b^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il1b^em1Smoc
• Name: interleukin 1 beta; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6430637
• Synonyms: Il1b^{em1(Luc-eGFP)Smoc}
• Gene: Il1b Location: Chr2:129206490-129213059 bp, - strand Genetic Position: Chr2, 62.97 cM, cytoband F
• Alliance: Il1b^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 genome editing technology was used to insert a luciferase gene, a viral 2A oligopeptide that mediates ribosomal skipping, an EGFP gene and polyA expression cassette into the gene start codon. (J:270618)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il1b Mutation: 21 strains or lines available

References

• Original: J:270618 Li J, et al., Acute pancreatic beta cell apoptosis by IL-1beta is responsible for postburn hyperglycemia: Evidence from humans and mice. Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):275-284
• All: 2 reference(s)