Hnf1a^tm1.1Smoc
Targeted Allele Detail

Summary

• Symbol: Hnf1a^tm1.1Smoc
• Name: HNF1 homeobox A; targeted mutation 1.1, Shanghai Model Organisms Center
• MGI ID: MGI:6430634
• Synonyms: Hnf1alpha^f
• Gene: Hnf1a Location: Chr5:115087039-115109121 bp, - strand Genetic Position: Chr5, 55.99 cM, cytoband F
• Alliance: Hnf1a^tm1.1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244892
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and a Frt-flanked PgkNeopolyA cassette were inserted into the second intron of the gene, and a second loxP site was inserted into the third intron. The neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:244892)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hnf1a Mutation: 33 strains or lines available

Notes

ES Cell line = SCR012

References

• Original: J:244892 Ni Q, et al., Deletion of HNF1alpha in hepatocytes results in fatty liver-related hepatocellular carcinoma in mice. FEBS Lett. 2017 Jul;591(13):1947-1957
• All: 1 reference(s)