Ptprz1^tm3.1Mno
Targeted Allele Detail

Summary

• Symbol: Ptprz1^tm3.1Mno
• Name: protein tyrosine phosphatase receptor type Z, polypeptide 1; targeted mutation 3.1, Masaharu Noda
• MGI ID: MGI:6430487
• Synonyms: Ptprz-deltaD2
• Gene: Ptprz1 Location: Chr6:22875501-23052915 bp, + strand Genetic Position: Chr6, 9.92 cM
• Alliance: Ptprz1^tm3.1Mno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276448
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A Ptprz-D2 knock-in allele in which the Pro (codon 1998-CCT) was substituted to a termination codon (TGA). An adjacent loxP-flanked neomycin selection cassette was removed via Cre-mediated recombination. (J:276448)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprz1 Mutation: 145 strains or lines available

References

• Original: J:276448 Tanga N, et al., Behavioral and neurological analyses of adult mice carrying null and distinct loss-of-receptor function mutations in protein tyrosine phosphatase receptor type Z (PTPRZ). PLoS One. 2019;14(6):e0217880
• All: 2 reference(s)