Eef1e1^tm1.1Hlee
Targeted Allele Detail

Summary

• Symbol: Eef1e1^tm1.1Hlee
• Name: eukaryotic translation elongation factor 1 epsilon 1; targeted mutation 1.1, Ho Lee
• MGI ID: MGI:6430437
• Synonyms: AIMP3^f
• Gene: Eef1e1 Location: Chr13:38829667-38843004 bp, - strand Genetic Position: Chr13, 18.38 cM, cytoband A5
• Alliance: Eef1e1^tm1.1Hlee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288140
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exons 2 and 3 floxed. (J:288140)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eef1e1 Mutation: 20 strains or lines available

References

• Original: J:288140 Kim SM, et al., AIMP3 depletion causes genome instability and loss of stemness in mouse embryonic stem cells. Cell Death Dis. 2018 Sep 24;9(10):972
• All: 2 reference(s)