Nsd2^tm1.1Bcgen
Targeted Allele Detail

Summary

• Symbol: Nsd2^tm1.1Bcgen
• Name: nuclear receptor binding SET domain protein 2; targeted mutation 1.1, Biocytogen LLC
• MGI ID: MGI:6423633
• Synonyms: Whsc1^fl
• Gene: Nsd2 Location: Chr5:33978069-34055319 bp, + strand Genetic Position: Chr5, 17.83 cM
• Alliance: Nsd2^tm1.1Bcgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243606
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites and an frt-flanked neomycin selection casssette were inserted to flank exons 3 and 4. The neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:243606)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nsd2 Mutation: 52 strains or lines available

References

• Original: J:243606 Li N, et al., AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest. 2017 Apr 03;127(4):1284-1302
• All: 4 reference(s)