Oprm1^tm4.1Yxp
Targeted Allele Detail

Summary

• Symbol: Oprm1^tm4.1Yxp
• Name: opioid receptor, mu 1; targeted mutation 4.1, Ying-Xian Pan
• MGI ID: MGI:6423573
• Synonyms: mE4M-129
• Gene: Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
• Alliance: Oprm1^tm4.1Yxp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243674
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: A stop codon was introduced at the 5' end of exon 4. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of exon 4. This allele affects variants: MOR-1, MOR-1H, MOR-1i, MOR1J, MOR-1G and MOR-1S. (J:243674)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Oprm1 Mutation: 53 strains or lines available

References

• Original: J:243674 Xu J, et al., Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine. J Clin Invest. 2017 Apr 03;127(4):1561-1573
• All: 1 reference(s)