Scd1^tm1Wst
Targeted Allele Detail

Summary

• Symbol: Scd1^tm1Wst
• Name: stearoyl-Coenzyme A desaturase 1; targeted mutation 1, Wilhelm Stoffel
• MGI ID: MGI:6423524
• Gene: Scd1 Location: Chr19:44382889-44396148 bp, - strand Genetic Position: Chr19, 37.98 cM
• Alliance: Scd1^tm1Wst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287758
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 2. Western blot analysis confirmed the absence of protein expression in the liver, skin, brain, and kidney. (J:287758)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scd1 Mutation: 26 strains or lines available

References

• Original: J:287758 Binczek E, et al., Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation. Biol Chem. 2007 Apr;388(4):405-18
• All: 1 reference(s)