Trim72^em1Mure
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trim72^em1Mure
• Name: tripartite motif-containing 72; endonuclease-mediated mutation 1, Elizbeth Murphy
• MGI ID: MGI:6416518
• Synonyms: TRIM72 C144S
• Gene: Trim72 Location: Chr7:127603121-127610205 bp, + strand Genetic Position: Chr7, 69.89 cM
• Alliance: Trim72^em1Mure page

Mutation origin

• Strain of Origin: (C57BL/6J x CBA/J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: TALEN-targeting (5'-ATCATCTCTTTTAATTTGTCCCATAGACACAGCTTCCACAACAAAAGATGCAGCTGCAGGAGGCATCCATGCGCAAAGAGAAGACTGTAGCGGTGCTGGAGCATCAGCTGGTGGAGGTG-3') modified cysteine 144. (J:283679)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trim72 Mutation: 32 strains or lines available

References

• Original: J:283679 Fillmore N, et al., A knock-in mutation at cysteine 144 of TRIM72 is cardioprotective and reduces myocardial TRIM72 release. J Mol Cell Cardiol. 2019 Nov;136:95-101
• All: 1 reference(s)