Ccdc8^tm1.1Yxi
Targeted Allele Detail

Summary

• Symbol: Ccdc8^tm1.1Yxi
• Name: coiled-coil domain containing 8; targeted mutation 1.1, Yue Xiong
• MGI ID: MGI:6416509
• Synonyms: Ccdc8^fl
• Gene: Ccdc8 Location: Chr7:16727827-16731440 bp, + strand Genetic Position: Chr7, 9.15 cM
• Alliance: Ccdc8^tm1.1Yxi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303998
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site followed by an frt-flanked neomycin resistance gene was inserted upstream of the single coding exon. A second loxP site was inserted downstream of this exon. Flp-mediated recombination removed the neo gene leaving the single exon floxed. (J:303998)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccdc8 Mutation: 24 strains or lines available

References

• Original: J:303998 Wang P, et al., Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development. J Clin Invest. 2019 Jul 25;129(10):4393-4407
• All: 1 reference(s)