Msrb3^em1Rlev
Endonuclease-mediated Allele Detail

Summary

• Symbol: Msrb3^em1Rlev
• Name: methionine sulfoxide reductase B3; endonuclease-mediated mutation 1, Robert Levine
• MGI ID: MGI:6415708
• Gene: Msrb3 Location: Chr10:120617001-120735006 bp, - strand Genetic Position: Chr10, 68.75 cM
• Alliance: Msrb3^em1Rlev page

Mutation origin

• Strain of Origin: B6.Cg-Msra^tm1Jmo Msrb1^tm1.1Rlev

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a 7 base pair deletion (CCGAGAG) in the exon 1. (J:287223)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Msrb3 Mutation: 19 strains or lines available

References

• Original: J:287223 Lai L, et al., Loss of methionine sulfoxide reductases increases resistance to oxidative stress. Free Radic Biol Med. 2019 Dec;145:374-384
• All: 1 reference(s)