Per1^tm1.1Gumz
Targeted Allele Detail

Summary

• Symbol: Per1^tm1.1Gumz
• Name: period circadian clock 1; targeted mutation 1.1, Michelle Gumz
• MGI ID: MGI:6415707
• Synonyms: Per1^fl
• Gene: Per1 Location: Chr11:68986043-69000786 bp, + strand Genetic Position: Chr11, 42.37 cM, cytoband B
• Alliance: Per1^tm1.1Gumz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278288
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 2 through 8 were floxed.The neomycin selection cassette was removed with Flp recombinase. (J:278288)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Per1 Mutation: 62 strains or lines available

References

• Original: J:278288 Douma LG, et al., Renal Na-handling defect associated with PER1-dependent nondipping hypertension in male mice. Am J Physiol Renal Physiol. 2018 Jun 1;314(6):F1138-F1144
• All: 2 reference(s)