Flvcr2^tm1.1Tda
Targeted Allele Detail

Summary

• Symbol: Flvcr2^tm1.1Tda
• Name: feline leukemia virus subgroup C cellular receptor 2; targeted mutation 1.1, Thomas Arnold
• MGI ID: MGI:6415546
• Synonyms: Flvcr2^FLEx
• Gene: Flvcr2 Location: Chr12:85793313-85860359 bp, + strand Genetic Position: Chr12, 39.8 cM
• Alliance: Flvcr2^tm1.1Tda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287134
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette, mutant loxP site, inverted 2A-EGFP-WPRE-pA cassette with a splice acceptor, loxP site and mutant loxP site were inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette. (J:287134)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flvcr2 Mutation: 25 strains or lines available

References

• Original: J:287134 Santander N, et al., Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier. J Clin Invest. 2020 May 5
• All: 1 reference(s)