Bace1^tm1.1Twr
Targeted Allele Detail

Summary

• Symbol: Bace1^tm1.1Twr
• Name: beta-site APP cleaving enzyme 1; targeted mutation 1.1, Thomas W Rosahl
• MGI ID: MGI:6415537
• Gene: Bace1 Location: Chr9:45749878-45775694 bp, + strand Genetic Position: Chr9, 25.22 cM
• Alliance: Bace1^tm1.1Twr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287115
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by lozP sites. An ajacent frt-flanked neomycin selection cassette was removed via FLP-mediated recombination. (J:287115)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bace1 Mutation: 29 strains or lines available

References

• Original: J:287115 Lombardo S, et al., BACE1 partial deletion induces synaptic plasticity deficit in adult mice. Sci Rep. 2019 Dec 27;9(1):19877
• All: 1 reference(s)