Rnf2^tm1.1Hgu
Targeted Allele Detail

Summary

• Symbol: Rnf2^tm1.1Hgu
• Name: ring finger protein 2; targeted mutation 1.1, MRC Human Genetics Unit
• MGI ID: MGI:6414568
• Synonyms: Ring1B^I53A
• Gene: Rnf2 Location: Chr1:151345149-151376747 bp, - strand Genetic Position: Chr1, 64.15 cM
• Alliance: Rnf2^tm1.1Hgu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283578
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: Gap repair produced the amino acid substitution of alanine for isoleucine at position 53 (53A) as well as introducing two silent restriction sites (SacI and XbaI) into exon 3. A floxed neomycin resistance cassette was introduced into intron 3 and removed by cre-mediated recombination. (J:283578)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rnf2 Mutation: 36 strains or lines available

References

• Original: J:283578 Illingworth RS, et al., The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development. Genes Dev. 2015 Sep 15;29(18):1897-902
• All: 3 reference(s)