Tg(Il4-HBEGF)2Kubo
Transgene Detail

Summary

• Symbol: Tg(Il4-HBEGF)2Kubo
• Name: transgene insertion 2, Masato Kubo
• MGI ID: MGI:6407406
• Synonyms: Bas-TRECK
• Transgene: Tg(Il4-HBEGF)2Kubo Location: unknown
• Alliance: Tg(Il4-HBEGF)2Kubo page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Il4-HBEGF)2Kubo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: Mice expressing the human DTR under the control of a 4kb 3'UTR element in the Il4 gene locus specifically regulate IL-4 expression in basophils, leading to basophil deletion. (J:181174)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:181174 Sawaguchi M, et al., Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness. J Immunol. 2012 Feb 15;188(4):1809-18
• All: 17 reference(s)