Gnas^tm5Lsw
Targeted Allele Detail

Summary

• Symbol: Gnas^tm5Lsw
• Name: GNAS complex locus; targeted mutation 5, Lee S Weinstein
• MGI ID: MGI:6407048
• Synonyms: E1^neo-fl
• Gene: Gnas Location: Chr2:174126113-174188537 bp, + strand Genetic Position: Chr2, 97.89 cM, cytoband E1-H3
• Alliance: Gnas^tm5Lsw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99237
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to contain a floxed neo at position -1601 (upstream of exon 1) and a third loxP site downstream of exon 1 at position 419. (J:99237)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnas Mutation: 53 strains or lines available

Notes

The version of this allele that does not contain the neomycin selection cassette, Gnas^tm5.1Lsw, has been analyzed.

References

• Original: J:99237 Chen M, et al., Alternative Gnas gene products have opposite effects on glucose and lipid metabolism. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7386-91
• All: 1 reference(s)