Lox^em1Mech
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lox^em1Mech
• Name: lysyl oxidase; endonuclease-mediated mutation 1, Robert P Mecham
• MGI ID: MGI:6406219
• Synonyms: Lox^Mut, Lox p.M292R
• Gene: Lox Location: Chr18:52649139-52662939 bp, - strand Genetic Position: Chr18, 28.22 cM
• Alliance: Lox^em1Mech page

Mutation origin

• Strain of Origin: (C57BL/6J x CBA/J)F2

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-mediated mutation induced a T to G point mutation that results in the amino acid substitution of arginine for methionine at position 292 (M292R). (J:237691)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lox Mutation: 23 strains or lines available

References

• Original: J:237691 Lee VS, et al., Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans. Proc Natl Acad Sci U S A. 2016 Aug 02;113(31):8759-64
• All: 2 reference(s)