Slc26a2^tm1.1Lyng
Targeted Allele Detail

Summary

• Symbol: Slc26a2^tm1.1Lyng
• Name: solute carrier family 26 (sulfate transporter), member 2; targeted mutation 1.1, Liu Yang
• MGI ID: MGI:6404520
• Synonyms: slc26a2^fl
• Gene: Slc26a2 Location: Chr18:61329926-61344668 bp, - strand Genetic Position: Chr18, 34.41 cM, cytoband D3
• Alliance: Slc26a2^tm1.1Lyng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286157
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3, which contains the ATG start codon. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of the coding sequence in exon 4. Flp-mediated recombination removed the selection cassette and left the coding sequence floxed. (J:286157)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc26a2 Mutation: 29 strains or lines available

References

• Original: J:286157 Zheng C, et al., Suppressing UPR-dependent overactivation of FGFR3 signaling ameliorates SLC26A2-deficient chondrodysplasias. EBioMedicine. 2019 Feb;40:695-709
• All: 1 reference(s)