Rad21^tm1.2Mmk
Targeted Allele Detail

Summary

• Symbol: Rad21^tm1.2Mmk
• Name: RAD21 cohesin complex component; targeted mutation 1.2, Matthias Merkenschlager
• MGI ID: MGI:6404448
• Gene: Rad21 Location: Chr15:51825636-51855143 bp, - strand Genetic Position: Chr15, 19.54 cM, cytoband D3
• Alliance: Rad21^tm1.2Mmk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286194
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 5 and an FRT-flanked puro cassette with a 3' loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the puro cassette. Cre-mediated recombination removed exons 5 and 6. (J:286194)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rad21 Mutation: 60 strains or lines available

References

• Original: J:286194 Du Z, et al., Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos. Mol Cell. 2020 Feb 20;77(4):825-839.e7
• All: 1 reference(s)