Parp1^tm1.1Zqw
Targeted Allele Detail

Summary

• Symbol: Parp1^tm1.1Zqw
• Name: poly (ADP-ribose) polymerase family, member 1; targeted mutation 1.1, Zhao-Qi Wang
• MGI ID: MGI:6403158
• Synonyms: PARP1^D993A, PARP1^Ki
• Gene: Parp1 Location: Chr1:180396456-180428564 bp, + strand Genetic Position: Chr1, 84.44 cM, cytoband H5
• Alliance: Parp1^tm1.1Zqw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249307
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 23 was replaced with a version containing an A>C point mutation that changes aspartic acid codon 933 into an alanine codon (p.D993A). The loxP site flanked neomycin resistance gene cassette that was inserted into intron 22 was removed through subsequent cre-mediated recombination. (J:249307)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Parp1 Mutation: 68 strains or lines available

References

• Original: J:249307 Schuhwerk H, et al., Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo. Nucleic Acids Res. 2017 Nov 02;45(19):11174-11192
• All: 1 reference(s)