Asah1^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Asah1^tm1.1Geno
• Name: N-acylsphingosine amidohydrolase 1; targeted mutation 1.1, Genoway
• MGI ID: MGI:6401406
• Gene: Asah1 Location: Chr8:41793234-41827810 bp, - strand Genetic Position: Chr8, 23.89 cM
• Alliance: Asah1^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:285931
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1, encoding the enzymes signal peptide, was flanked by loxP sites. An FRT-flanked neomycin selection cassette was inserted and removed via Flp-mediated recombination leaving exon 1 floxed. (J:285931)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Asah1 Mutation: 43 strains or lines available

References

• Original: J:285931 Beckmann N, et al., Pathological manifestations of Farber disease in a new mouse model. Biol Chem. 2018 Sep 25;399(10):1183-1202
• All: 8 reference(s)