Trp53^em1Yoli
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trp53^em1Yoli
• Name: transformation related protein 53; endonuclease-mediated mutation 1, Yong Li
• MGI ID: MGI:6393635
• Synonyms: p53^1175C, p53^C
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^em1Yoli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281362
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: Zinc finger endonuclease-targeting mutated the polyadenylation signal sequence from AATAAA to AATACA to mimic human rs78378222. (J:281362)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^em1Yoli

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 232 strains or lines available

Notes

Lentiviral gene trap injected into zygotes.

References

• Original: J:281362 Deng Q, et al., Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant. Nat Commun. 2019 Nov 7;10(1):5061
• All: 1 reference(s)