Fmr1^tm1Drnl
Targeted Allele Detail

Summary

• Symbol: Fmr1^tm1Drnl
• Name: fragile X messenger ribonucleoprotein 1; targeted mutation 1, Jennifer Darnell
• MGI ID: MGI:6393408
• Synonyms: Fmr1^cTag
• Gene: Fmr1 Location: ChrX:67722147-67761569 bp, + strand Genetic Position: ChrX, 34.83 cM
• Alliance: Fmr1^tm1Drnl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:285231
• Parent Cell Line: CY2.4 (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 17. The targeting vector also inserted downstream of the endogenous exon 17 a neomycin resistance cassette, loxP site and modified exon 17 with an inframe AcGFP reporter gene downstream of the coding sequence with the untranslated sequence preserved. (J:285231)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fmr1 Mutation: 30 strains or lines available

References

• Original: J:285231 Van Driesche SJ, et al., FMRP binding to a ranked subset of long genes is revealed by coupled CLIP and TRAP in specific neuronal cell types. bioRxiv. 2019
• All: 3 reference(s)