Trex1^tm1.1Kpk
Targeted Allele Detail

Summary

• Symbol: Trex1^tm1.1Kpk
• Name: three prime repair exonuclease 1; targeted mutation 1.1, Klaus-Peter Knobeloch
• MGI ID: MGI:6393254
• Synonyms: Trex1^F1Freiburg
• Gene: Trex1 Location: Chr9:108887000-108888791 bp, - strand Genetic Position: Chr9, 59.63 cM
• Alliance: Trex1^tm1.1Kpk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:285031
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP-site and an FRT-flanked neomycin resistance gene was inserted into upstream of Trex1 Exon2, and second loxP-site was inserted into downstream of the Exon2. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:285031)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trex1 Mutation: 29 strains or lines available

References

• Original: J:285031 Peschke K, et al., Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity. J Immunol. 2016 Sep 15;197(6):2157-66
• All: 2 reference(s)