Myd88^tm1.1Mpa
Targeted Allele Detail

Summary

• Symbol: Myd88^tm1.1Mpa
• Name: myeloid differentiation primary response gene 88; targeted mutation 1.1, Manolis Pasparakis
• MGI ID: MGI:6392915
• Synonyms: MyD88-floxed
• Gene: Myd88 Location: Chr9:119165000-119169084 bp, - strand Genetic Position: Chr9, 71.33 cM
• Alliance: Myd88^tm1.1Mpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262898
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 2-6 of the gene were flanked by loxP sites and a cassette consisting of an adenoviral splice acceptor site fused to an IRES and a GFP gene ws inserted downstream of the second loxP site. An frt-flanked neomycin selection cassette was removed via FLP-mediated recombination. Upon cre-mediated recombination, exons 2-6 are removed and the GFP reporter gene is expressed under the endogenous promoter. (J:262898)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myd88 Mutation: 51 strains or lines available

References

• Original: J:262898 Vlantis K, et al., TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice. Gut. 2016 Jun;65(6):935-43
• All: 10 reference(s)