Cadm4^tm1.2Pele
Targeted Allele Detail

Summary

• Symbol: Cadm4^tm1.2Pele
• Name: cell adhesion molecule 4; targeted mutation 1.2, Elior Peles
• MGI ID: MGI:6392891
• Gene: Cadm4 Location: Chr7:24181448-24203958 bp, + strand Genetic Position: Chr7, 11.03 cM, cytoband A3-B2
• Alliance: Cadm4^tm1.2Pele page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269651
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 6. Flp mediated recombination removed the neo cassettea and cre-mediated recombination removed exons 2-6. (J:199632)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cadm4 Mutation: 12 strains or lines available

References

• Original: J:199632 Golan N, et al., Genetic deletion of Cadm4 results in myelin abnormalities resembling charcot-marie-tooth neuropathy. J Neurosci. 2013 Jul 3;33(27):10950-61
• All: 4 reference(s)